# Selected Publications **2026** Xie G, Liu Y, Qi X, Bhattacherjee A, Zhang C, Zhang Y. A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain in male mice. Nat Commun. 2026 Jan 29;17(1):2134. doi: 10.1038/s41467-026-69001-2. PMID: 41611731; PMCID: PMC12957525. **2025** Wang Y, Zhang W, Zhang C, Van HQT, Seino T, Zhang Y. Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice. Cell Res. 2025 Jan;35(1):45-58. doi: 10.1038/s41422-024-01057-5. Epub 2025 Jan 2. PMID: 39743633; PMCID: PMC11701126. Marin-Rodero M, Cintado E, Walker AJ, Jayewickreme T, Pinho-Ribeiro FA, Richardson Q, Jackson R, Chiu IM, Benoist C, Stevens B, Trejo JL, Mathis D. The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis. Sci Immunol. 2025 Feb 28;10(104):eadu2910. doi: 10.1126/sciimmunol.adu2910. Epub 2025 Feb 28. PMID: 39873623. Avilés EC, Wang SK, Patel S, Cordero S, Shi S, Lin L, Kefalov VJ, Goodrich LV, Cepko CL, Xue Y. ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells. J Gen Physiol. 2025 Mar 3;157(2):e202413642. doi: 10.1085/jgp.202413642. Epub 2025 Feb 4. PMID: 39903280; PMCID: PMC11793021. Jin SX, Bellier JP, Wells A, LIopis PM, Anekal PV, Tresback JS, Caldarone BJ, Liu L, Li S, Dettmer U, Ramalingam N, Selkoe DJ. Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice. Alzheimers Dement. 2025 Apr;21(4):e70194. doi: 10.1002/alz.70194. PMID: 40302031; PMCID: PMC12040739. Liu Y, Wang Y, Xie G, Yang Q, Bhattacherjee A, Zhang C, Zhang Y. A molecularly defined mPFC-BLA circuit specifically regulates social novelty preference. Sci Adv. 2025 Apr 25;11(17):eadt9008. doi: 10.1126/sciadv.adt9008. Epub 2025 Apr 23. PMID: 40267197; PMCID: PMC12017316. Zhang Y, Watson B, Rattan A, Lee T, Chawla S, Geistlinger L, Guan Y, Lord FB, Ma M, Miwa T, Golla M, Caldarone BJ, Song WC, Moffitt JR, Carroll MC. A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice. Nat Commun. 2025 Dec 2. doi: 10.1038/s41467-025-66048-5. Epub ahead of print. PMID: 41331253. Savage J, Rai A, Lee JD, Banahan J, Dujic K, Nunez M, Caldarone B, Ghoshal S, Slack FJ, Mavrikaki M. Age-dependent transcriptomic effects of morphine in the frontal cortex of female mice. Neuropharmacology. 2025 Dec 16;286:110809. doi: 10.1016/j.neuropharm.2025.110809. Epub ahead of print. PMID: 41412512. **2024** Iske J, Roesel MJ, Martin F, Schroeter A, Matsunaga T, Maenosono R, Tripathi U, Xiao Y, Nian Y, Caldarone BJ, Vondran FWR, Sage PT, Azuma H, Abdi R, Elkhal A, Pirtskhalava T, Tchkonia T, Kirkland JL, Zhou H, Tullius SG. Transplanting old organs promotes senescence in young recipients. Am J Transplant. 2024 Mar;24(3):391-405. doi: 10.1016/j.ajt.2023.10.013. Epub 2023 Oct 31. PMID: 37913871; PMCID: PMC10922683. Hochbaum DR, Hulshof L, Urke A, Wang W, Dubinsky AC, Farnsworth HC, Hakim R, Lin S, Kleinberg G, Robertson K, Park C, Solberg A, Yang Y, Baynard C, Nadaf NM, Beron CC, Girasole AE, Chantranupong L, Cortopassi MD, Prouty S, Geistlinger L, Banks AS, Scanlan TS, Datta SR, Greenberg ME, Boulting GL, Macosko EZ, Sabatini BL. Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration. Cell. 2024 Oct 3;187(20):5679-5697.e23. doi: 10.1016/j.cell.2024.07.041. Epub 2024 Aug 22. PMID: 39178853; PMCID: PMC11455614. Liu Y, Wang Y, Zhao ZD, Xie G, Zhang C, Chen R, Zhang Y. A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis. Nat Metab. 2024 Aug;6(8):1616-1631. doi: 10.1038/s42255-024-01100-0. Epub 2024 Aug 15. Erratum in: Nat Metab. 2025 Apr;7(4):856. doi: 10.1038/s42255-025-01285-y. PMID: 39147933; PMCID: PMC11349581. da Cruz Rodrigues KC, Kim SC, Uner AA, Hou ZS, Young J, Campolim C, Aydogan A, Chung B, Choi A, Yang WM, Kim WS, Prevot V, Caldarone BJ, Lee H, Kim YB. LRP1 in GABAergic neurons is a key link between obesity and memory function. Mol Metab. 2024 Jun;84:101941. doi: 10.1016/j.molmet.2024.101941. Epub 2024 Apr 16. PMID: 38636794; PMCID: PMC11058729. Zhang H, Leitner DR, Hasegawa Y, Waldor MK. Peripheral serotonergic neurons regulate gut motility and anxiety-like behavior. Curr Biol. 2024 Feb 26;34(4):R133-R134. doi: 10.1016/j.cub.2023.12.072. PMID: 38412819; PMCID: PMC10921988. Varma C, Schroeder MK, Price BR, Khan KA, Curty da Costa E, Hochman-Mendez C, Caldarone BJ, Lemere CA. Long-Term, Sex-Specific Effects of GCRsim and Gamma Irradiation on the Brains, Hearts, and Kidneys of Mice with Alzheimer's Disease Mutations. Int J Mol Sci. 2024 Aug 16;25(16):8948. doi: 10.3390/ijms25168948. PMID: 39201636; PMCID: PMC11355020. **2023** Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Loss of epigenetic information as a cause of mammalian aging. Cell. 2024 Feb 29;187(5):1312-1313. doi: 10.1016/j.cell.2024.01.049. Erratum for: Cell. 2023 Jan 19;186(2):305-326.e27. doi: 10.1016/j.cell.2022.12.027. PMID: 38428398. Hinshaw RG, Schroeder MK, Ciola J, Varma C, Colletti B, Liu B, Liu GG, Shi Q, Williams JP, O'Banion MK, Caldarone BJ, Lemere CA. High-Energy, Whole-Body Proton Irradiation Differentially Alters Long-Term Brain Pathology and Behavior Dependent on Sex and Alzheimer's Disease Mutations. Int J Mol Sci. 2023 Feb 10;24(4):3615. doi: 10.3390/ijms24043615. PMID: 36835027; PMCID: PMC9965515. Langston PK, Sun Y, Ryback BA, Mueller AL, Spiegelman BM, Benoist C, Mathis D. Regulatory T cells shield muscle mitochondria from interferon-γ-mediated damage to promote the beneficial effects of exercise. Sci Immunol. 2023 Nov 3;8(89):eadi5377. doi: 10.1126/sciimmunol.adi5377. Epub 2023 Nov 3. PMID: 37922340; PMCID: PMC10860652. Aw E, Zhang Y, Yalcin E, Herrmann U, Lin SL, Langston K, Castrillon C, Ma M, Moffitt JR, Carroll MC. Spatial enrichment of the type 1 interferon signature in the brain of a neuropsychiatric lupus murine model. Brain Behav Immun. 2023 Nov;114:511-522. doi: 10.1016/j.bbi.2023.06.021. Epub 2023 Jun 25. Erratum in: Brain Behav Immun. 2024 Feb;116:419. doi: 10.1016/j.bbi.2023.11.024. PMID: 37369340; PMCID: PMC10918751. Qiu Y, Shen X, Ravid O, Atrakchi D, Rand D, Wight AE, Kim HJ, Liraz-Zaltsman S, Cooper I, Schnaider Beeri M, Cantor H. Definition of the contribution of an Osteopontin-producing CD11c+ microglial subset to Alzheimer's disease. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2218915120. doi: 10.1073/pnas.2218915120. Epub 2023 Feb 2. PMID: 36730200; PMCID: PMC9963365. Yadav S, Waldeck-Weiermair M, Spyropoulos F, Bronson R, Pandey AK, Das AA, Sisti AC, Covington TA, Thulabandu V, Caplan S, Chutkow W, Steinhorn B, Michel T. Sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress in chemogenetic transgenic mouse lines. Nat Commun. 2023 May 29;14(1):3094. doi: 10.1038/s41467-023-38961-0. PMID: 37248315; PMCID: PMC10227029. **2022** He D, Xu H, Zhang H, Tang R, Lan Y, Xing R, Li S, Christian E, Hou Y, Lorello P, Caldarone B, Ding J, Nguyen L, Dionne D, Thakore P, Schnell A, Huh JR, Rozenblatt-Rosen O, Regev A, Kuchroo VK. Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function. Immunity. 2022 Jan 11;55(1):159-173.e9. doi: 10.1016/j.immuni.2021.12.001. Epub 2022 Jan 3. PMID: 34982959; PMCID: PMC9074730. Agrud A, Subburaju S, Goel P, Ren J, Kumar AS, Caldarone BJ, Dai W, Chavez J, Fukumura D, Jain RK, Kloner RA, Vasudevan A. Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction. Sci Rep. 2022 Mar 22;12(1):4922. doi: 10.1038/s41598-022-08806-9. PMID: 35318369; PMCID: PMC8941104. Chen R, Liu Y, Djekidel MN, Chen W, Bhattacherjee A, Chen Z, Scolnick E, Zhang Y. Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis. Sci Adv. 2022 Mar 4;8(9):eabm1077. doi: 10.1126/sciadv.abm1077. Epub 2022 Mar 4. PMID: 35245111; PMCID: PMC8896793. Zhao ZD, Han X, Chen R, Liu Y, Bhattacherjee A, Chen W, Zhang Y. A molecularly defined D1 medium spiny neuron subtype negatively regulates cocaine addiction. Sci Adv. 2022 Aug 12;8(32):eabn3552. doi: 10.1126/sciadv.abn3552. Epub 2022 Aug 12. PMID: 35960793; PMCID: PMC9374336. **2021** Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, Selkoe DJ. A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice. Ann Neurol. 2021 Jan;89(1):74-90. doi: 10.1002/ana.25920. Epub 2020 Oct 23. PMID: 32996158; PMCID: PMC7756464. Yilmaz M, Yalcin E, Presumey J, Aw E, Ma M, Whelan CW, Stevens B, McCarroll SA, Carroll MC. Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice. Nat Neurosci. 2021 Feb;24(2):214-224. doi: 10.1038/s41593-020-00763-8. Epub 2020 Dec 22. PMID: 33353966; PMCID: PMC8086435. Sun T, Shi Q, Zhang Y, Power C, Hoesch C, Antonelli S, Schroeder MK, Caldarone BJ, Taudte N, Schenk M, Hettmann T, Schilling S, McDannold NJ, Lemere CA. Focused ultrasound with anti-pGlu3 Aβ enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells. J Control Release. 2021 Aug 10;336:443-456. doi: 10.1016/j.jconrel.2021.06.037. Epub 2021 Jun 26. PMID: 34186148; PMCID: PMC8373822. Qiu C, Albayram O, Kondo A, Wang B, Kim N, Arai K, Tsai CY, Bassal MA, Herbert MK, Washida K, Angeli P, Kozono S, Stucky JE, Baxley S, Lin YM, Sun Y, Rotenberg A, Caldarone BJ, Bigio EH, Chen X, Tenen DG, Zeidel M, Lo EH, Zhou XZ, Lu KP. Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice. Sci Transl Med. 2021 Jun 2;13(596):eaaz7615. doi: 10.1126/scitranslmed.aaz7615. PMID: 34078745; PMCID: PMC8272885. Islam MR, Valaris S, Young MF, Haley EB, Luo R, Bond SF, Mazuera S, Kitchen RR, Caldarone BJ, Bettio LEB, Christie BR, Schmider AB, Soberman RJ, Besnard A, Jedrychowski MP, Kim H, Tu H, Kim E, Choi SH, Tanzi RE, Spiegelman BM, Wrann CD. Exercise hormone irisin is a critical regulator of cognitive function. Nat Metab. 2021 Aug;3(8):1058-1070. doi: 10.1038/s42255-021-00438-z. Epub 2021 Aug 20. Erratum in: Nat Metab. 2021 Oct;3(10):1432. doi: 10.1038/s42255-021-00476-7. PMID: 34417591; PMCID: PMC10317538. Schroeder MK, Liu B, Hinshaw RG, Park MA, Wang S, Dubey S, Liu GG, Shi Q, Holton P, Reiser V, Jones PA, Trigg W, Di Carli MF, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA. Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice. Int J Mol Sci. 2021 Dec 10;22(24):13305. doi: 10.3390/ijms222413305. PMID: 34948098; PMCID: PMC8703695. Melzer S, Newmark ER, Mizuno GO, Hyun M, Philson AC, Quiroli E, Righetti B, Gregory MR, Huang KW, Levasseur J, Tian L, Sabatini BL. Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories. Cell. 2021 Oct 28;184(22):5622-5634.e25. doi: 10.1016/j.cell.2021.09.013. Epub 2021 Oct 4. PMID: 34610277; PMCID: PMC8556345. Chen R, Blosser TR, Djekidel MN, Hao J, Bhattacherjee A, Chen W, Tuesta LM, Zhuang X, Zhang Y. Decoding molecular and cellular heterogeneity of mouse nucleus accumbens. Nat Neurosci. 2021 Dec;24(12):1757-1771. doi: 10.1038/s41593-021-00938-x. Epub 2021 Oct 18. PMID: 34663959; PMCID: PMC8639815. Wang SK, Xue Y, Cepko CL. Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration. JCI Insight. 2021 Aug 23;6(16):e150796. doi: 10.1172/jci.insight.150796. PMID: 34197341; PMCID: PMC8409989. **2020** Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O'Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA. Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice. Alzheimers Res Ther. 2020 Jan 13;12(1):12. doi: 10.1186/s13195-019-0579-8. PMID: 31931873; PMCID: PMC6958628. Lyon KA, Rood BD, Wu L, Senft RA, Goodrich LV, Dymecki SM. Sex-Specific Role for Dopamine Receptor D2 in Dorsal Raphe Serotonergic Neuron Modulation of Defensive Acoustic Startle and Dominance Behavior. eNeuro. 2020 Nov 19;7(6):ENEURO.0202-20.2020. doi: 10.1523/ENEURO.0202-20.2020. PMID: 33214315; PMCID: PMC7768286. Zou C, Mifflin L, Hu Z, Zhang T, Shan B, Wang H, Xing X, Zhu H, Adiconis X, Levin JZ, Li F, Liu CF, Liu JS, Yuan J. Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer's Disease. Cell Rep. 2020 Dec 8;33(10):108447. doi: 10.1016/j.celrep.2020.108447. PMID: 33296651. Wang SK, Xue Y, Cepko CL. Microglia modulation by TGF-β1 protects cones in mouse models of retinal degeneration. J Clin Invest. 2020 Aug 3;130(8):4360-4369. doi: 10.1172/JCI136160. PMID: 32352930; PMCID: PMC7410072. **2019** Albayram O, MacIver B, Mathai J, Verstegen A, Baxley S, Qiu C, Bell C, Caldarone BJ, Zhou XZ, Lu KP, Zeidel M. Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways. Sci Rep. 2019 Jun 14;9(1):8646. doi: 10.1038/s41598-019-45234-8. PMID: 31201348; PMCID: PMC6570649. Liu B, Hinshaw RG, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Shi Q, Holton P, Trojanczyk L, Reiser V, Jones PA, Trigg W, Di Carli MF, Lorello P, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA. Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer's-like transgenic mice. Sci Rep. 2019 Aug 20;9(1):12118. doi: 10.1038/s41598-019-48615-1. PMID: 31431669; PMCID: PMC6702228. Goldman A, Smalley JL, Mistry M, Krenzlin H, Zhang H, Dhawan A, Caldarone B, Moss SJ, Silbersweig DA, Lawler SE, Braun IM. A computationally inspired in-vivo approach identifies a link between amygdalar transcriptional heterogeneity, socialization and anxiety. Transl Psychiatry. 2019 Dec 9;9(1):336. doi: 10.1038/s41398-019-0677-1. PMID: 31819040; PMCID: PMC6901550. Tuesta LM, Djekidel MN, Chen R, Lu F, Wang W, Sabatini BL, Zhang Y. In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function. Nat Commun. 2019 Jun 7;10(1):2508. doi: 10.1038/s41467-019-10267-0. PMID: 31175277; PMCID: PMC6555850. Bhattacherjee A, Djekidel MN, Chen R, Chen W, Tuesta LM, Zhang Y. Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction. Nat Commun. 2019 Sep 13;10(1):4169. doi: 10.1038/s41467-019-12054-3. PMID: 31519873; PMCID: PMC6744514. Rajsombath MM, Nam AY, Ericsson M, Nuber S. Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice. J Neurosci. 2019 Sep 18;39(38):7628-7640. doi: 10.1523/JNEUROSCI.0313-19.2019. Epub 2019 Aug 12. PMID: 31405930; PMCID: PMC6750939. **2018** Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 2018 Oct 10;100(1):75-90.e5. doi: 10.1016/j.neuron.2018.09.014. PMID: 30308173; PMCID: PMC6211795. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23. PMID: 30146158; PMCID: PMC6128749.